I-epidermis eyomileyo ithetha ukuba umqobo wesikhumba uphazamisekile, i-lipids ilahlekile, iiprotheni ziyancipha

Emva komonakalo oqatha okanye ongapheliyo kwisithintelo se-epidermal, indlela yokulungisa ezenzekelayo yolusu iya kukhawulezisa ukuveliswa kweekeratinocytes, inciphise ixesha lokutshintshwa kweeseli ze-epidermal, kwaye ilamle ukuveliswa kunye nokukhululwa kwee-cytokines, okukhokelela kwi-hyperkeratosis kunye nokuvutha okuncinci kolusu. . Oku kukwafana neempawu zesikhumba esomileyo.

Ukuvuvukala kwendawo kunokunyusa ukomisa kwesikhumba, eqinisweni, ukuchithwa kwesithintelo se-epidermal kukhuthaza ukuhlanganiswa kunye nokukhululwa kwechungechunge lwe-cytokines e-pro-inflammatory, njenge-IL-1he TNF, ukwenzela ukuba iiseli ze-phagocytic immune, ngakumbi i-neutrophils, zitshatyalaliswe. Emva kokukhangwa kwindawo eyomileyo, emva kokufikelela kwindawo ekuya kuyo, i-neutrophils ikhupha i-leukocyte elastase, i-cathepsin G, i-protease 3, kunye ne-collagenase kwii-tissue ezijikelezayo, kunye nefom kunye nokuphucula i-protease kwi-keratinocytes. Iziphumo ezinokubakho zemisebenzi yeprotease egqithisileyo: 1. Ukonakala kweseli; 2. Ukukhululwa kwe-cytokines e-pro-inflammatory; 3. Ukuwohloka kwangaphambili koqhagamshelwano lweeseli-zeseli ezikhuthaza i-cell mitosis. Umsebenzi we-proteolytic enzyme kwisikhumba esomileyo, esinokuchaphazela imithambo-luvo kwi-epidermis, inxulunyaniswa ne-pruritus kunye neentlungu. Ukusetyenziswa kwezihloko ze-tranexamic acid kunye ne-α1-antitrypsin (i-protease inhibitor) kwi-xerosis iyasebenza, ebonisa ukuba i-xeroderma inxulumene nomsebenzi we-proteolytic enzyme.

I-epidermis eyomileyo ithetha ukubaumqobo wesikhumba uphazamisekile, i-lipids ilahlekile, iiprotheni ziyancipha, kwaye izinto ezivuthayo zendawo zikhutshwa.Ukomisa kwesikhumba okubangelwa ngumonakalo womqoboihluke ekomeni okubangelwa ukunciphisa i-sebum secretion, kwaye umphumo we-lipid supplementation elula uhlala uhluleka ukuhlangabezana nokulindela. Izithambiso zokuthambisa eziphuhliselwe umonakalo womqobo akufanele zongeze kuphela izinto zokuthambisa i-stratum corneum, ezinje nge-ceramides, izinto zokuthambisa zendalo, njl. iikeratinocytes. Umqobo wokomisa ulusu uhlala uhamba kunye ne-pruritus, kwaye ukongezwa kwe-antipruritic actives kufuneka kuthathelwe ingqalelo.