I-epidermis eyomileyo ithetha ukuba umqobo wolusu uyaphazamiseka, amafutha ayalahleka, iiproteni ziyancitshiswa

Emva komonakalo omkhulu okanye ongapheliyo kumqobo we-epidermal, indlela yokulungisa ulusu ezenzekelayo iya kukhawulezisa ukuveliswa kweekeratinocytes, inciphise ixesha lokutshintshwa kweeseli ze-epidermal, kwaye ilawule ukuveliswa nokukhululwa kwee-cytokines, okubangela i-hyperkeratosis kunye nokudumba okuncinci kolusu. Oku kukwaqhelekile kwiimpawu zolusu olomileyo.

Ukudumba kwendawo kunokwenza ukoma kwesikhumba kube mandundu, eneneni, ukuqhekeka komqobo we-epidermal kukhuthaza ukwenziwa kunye nokukhululwa kothotho lwee-cytokines ezibangela ukuvuvukala, ezifana ne-IL-1he TNF, ukuze iiseli zomzimba ze-phagocytic, ngakumbi ii-neutrophils, zitshatyalaliswe. Emva kokutsalwa kwindawo eyomileyo, emva kokufikelela kwindawo eya kuyo, ii-neutrophils zikhupha i-leukocyte elastase, i-cathepsin G, i-protease 3, kunye ne-collagenase kwizicubu ezijikelezileyo, kwaye zenze kwaye zityebise i-protease kwi-keratinocytes. Iziphumo ezinokubakho zomsebenzi ogqithisileyo we-protease: 1. Ukonakala kweseli; 2. Ukukhululwa kwee-cytokines ezibangela ukuvuvukala; 3. Ukonakala kwangaphambi kwexesha koqhagamshelwano lweseli-ukuya kwiseli olukhuthaza i-cell mitosis. Umsebenzi we-enzyme ye-proteolytic kulusu olomileyo, olunokuchaphazela nemithambo-luvo kwi-epidermis, lunxulunyaniswa nokurhawuzelelwa kunye nentlungu. Ukusetyenziswa kwe-tranexamic acid kunye ne-α1-antitrypsin (i-protease inhibitor) kwi-xerosis kuyasebenza, nto leyo ebonisa ukuba i-xeroderma inxulunyaniswa nomsebenzi we-enzyme ye-proteolytic.

I-epidermis eyomileyo ithetha ukubaumqobo wolusu uphazamisekile, ii-lipids ziyalahleka, iiproteni ziyancitshiswa, kwaye izinto ezibangela ukudumba kwasekuhlaleni ziyakhutshwa.Ukoma kolusu okubangelwa kukonakala komqoboyahlukile kukoma okubangelwa kukuncipha kokukhutshwa kwe-sebum, kwaye isiphumo sokongeza amafutha ngokulula sidla ngokungahlangabezani nolindelo. Izithambiso zokufumisa eziphuhliswe ngenxa yomonakalo womqobo akufuneki zongeze kuphela izinto zokufumisa ze-stratum corneum, ezifana nee-ceramides, izinto zokufumisa zendalo, njl.njl., kodwa zikwathathele ingqalelo nemiphumo yokwahlukana kwe-antioxidant, anti-inflammatory, kunye ne-anti-cell, ngaloo ndlela kunciphisa ukwahlukana okungaphelelanga kwee-keratinocytes. Ukoma kolusu oluthintelweyo kudla ngokuhamba ne-pruritus, kwaye ukongezwa kwezinto ezithintela ukufunxa kufuneka kuqwalaselwe.