Indlela entsha yonyango lwe-rosacea kusetyenziswa itekhnoloji ye-pulse egqwesileyo: kwi-vivo kunye nezifundo zeklinikhi

Imvelaphi:I-Rosacea yisifo esingapheliyo sokuvuvukala kwesikhumba esichaphazela ubuso, kwaye umphumo wonyango wangoku awunelisi. Ngokusekelwe kwi-photomodulation ye-teknoloji ye-pulse ephezulu (OPT), siphuhlise imodi yonyango yenoveli, oko kukuthi, i-OPT ephuculweyo enamandla aphantsi, i-pulses ezintathu, kunye nobubanzi be-pulse ende (AOPT-LTL).

Iinjongo:Sijonge ukuphonononga ukuba nokwenzeka kunye neendlela ezisisiseko zemolekyuli zonyango lwe-AOPT-LTL kwimodeli yempuku efana ne-rosacea. Ngaphezu koko, siye savavanya ukhuseleko kunye nokusebenza kakuhle kwizigulane ezine-erythematotelangiectatic rosacea (ETR).

Impahla nenkqubo:Uhlalutyo lwe-morphological, histological, kunye ne-immunohistochemical lwalusetyenziselwa ukuphanda ukusebenza kunye neendlela zonyango lwe-AOPT-LTL kwi-LL-37-induced rosacea-like mouse model. Ngaphezu koko, izigulane ze-23 ezine-ETR zibandakanyiwe kwaye zafumana amaxesha ahlukeneyo zonyango kwiiveki ze-2 kuxhomekeke kubunzima bemeko yabo. Umphumo wonyango wavavanywa ngokuthelekisa iifoto zeklinikhi kwisiseko, iveki ye-1, kunye neenyanga ze-3 emva kwonyango, idibene nexabiso elibomvu, i-GFSS, kunye namanqaku e-CEA.

Iziphumo:Emva kokunyangwa kwe-AOPT-LTL yeempuku, sabona ukuba i-rosacea-like phenotype, i-infiltration cell cell infiltration, kunye ne-vascular abnormalities yaphuculwa kakhulu, kwaye ukubonakaliswa kweemolekyuli eziphambili ze-rosacea kwakuvinjelwe kakhulu. Kuphononongo lweklinikhi, unyango lwe-AOPT-LTL luveze iziphumo zonyango ezanelisayo kwi-erythema kunye nokugungxulwa kwezigulane ze-ETR. Akuzange kubonwe ziziganeko ezimbi kakhulu.

Izigqibo:I-AOPT-LTL yindlela ekhuselekileyo nesebenzayo yonyango lwe-ETR.