Ihomoni iyehla ngokukhula, kuquka i-estrogen, i-testosterone, i-dehydroepiandrosterone sulfate, kunye nehomoni yokukhula. Iziphumo zehomoni eluswini zininzi, kubandakanya ukonyuka komxholo we-collagen, ukonyuka kobunzima bolusu, kunye nokuphuculwa kolusu. Phakathi kwazo, impembelelo ye-estrogen ibonakala ngakumbi, kodwa indlela yempembelelo yayo kwiiseli ayikaqondwa kakuhle. Umphumo we-estrogen esikhumbeni ubonakaliswa ikakhulu nge-keratinocytes ye-epidermis, i-fibroblasts kunye ne-melanocytes ye-dermis, kunye neeseli ze-follicle zeenwele kunye ne-sebaceous glands. Xa amandla amabhinqa okuvelisa i<em>estrogen encipha, inkqubo yokuguga kwesikhumba iyakhawuleza. Ukunqongophala kwehomoni ye-estradiol kunciphisa umsebenzi we-basal layer ye-epidermis kunye nokunciphisa ukuhlanganiswa kwe-collagen kunye ne-elastic fibers, zonke eziyimfuneko ekugcineni ukuqina kwesikhumba. Ukuhla kwamanqanaba e-estrogen e-postmenopausal akukhokelela kuphela ekunciphiseni umxholo we-collagen yesikhumba, kodwa kunye ne-metabolism yeeseli ze-dermal zichatshazelwa ngamanqanaba e-estrogen aphantsi kwe-postmenopausal, kwaye olu tshintsho lunokutshintshwa ngokukhawuleza ngokusetyenziswa kwe-estrogen ye-topical. Iimvavanyo ziqinisekisile ukuba i-estrogen yabasetyhini inokunyusa i-collagen, igcine ubukhulu bolusu, kwaye igcine ukufuma kwesikhumba kunye nomsebenzi womqobo we-stratum corneum ngokunyusa i-acidic glycosaminoglycans kunye ne-hyaluronic acid, ukuze ulusu lugcine ukuqina okulungileyo. Kungabonwa ukuba ukwehla komsebenzi we-endocrine womzimba kukwayenye yezinto ezibalulekileyo ezinempembelelo kwindlela yokuguga kwesikhumba.
Ukuncitshiswa kwemfihlo evela kwi-pituitary, i-adrenal, kunye ne-gonads igalelo kwiinguqu ezibonakalayo emzimbeni kunye nolusu lwe-phenotype kunye neendlela zokuziphatha ezinxulumene nokuguga. Amanqanaba e-Serum ye-17β-estradiol, i-dehydroepiandrosterone, i-progesterone, i-hormone yokukhula, kunye ne-hormone yabo ephantsi ye-insulin ukukhula factor (IGF) -ndiyanciphisa ngobudala. Nangona kunjalo, amanqanaba e-hormone yokukhula kunye ne-IGF-I kwi-serum yesilisa yehla kakhulu, kwaye ukuhla kwamanqanaba e-hormone kwezinye iindawo kunokuthi kwenzeke kwinqanaba elidala. IiHormones zinokuchaphazela indlela yolusu kunye nomsebenzi, ukutyhutyha ulusu, ukuphilisa, i-cortical lipogenesis, kunye nemetabolism yolusu. Unyango lokubuyisela i-Estrogen lunokuthintela ukuyeka ukuya exesheni kunye nokuguga okungapheliyo kolusu.
——”Skin Epiphysiology” Yinmao Dong, Laiji Ma, Chemical Industry Press
Ngoko ke, njengoko sikhula, ingqalelo yethu kwiimeko zolusu kufuneka inyuke ngokuthe ngcembe. Singasebenzisa ezinye iingcaliizixhobo zokuhlalutya ulusuukujonga kwaye uqikelele inqanaba lolusu, uqikelele iingxaki zesikhumba kwangoko, kwaye ujongane nazo ngenkuthalo.
Ixesha lokuposa: Jan-05-2023
