Iingcebiso Zokhathalelo Lolusu——Iimpawu Ezichaphazela Ukunwebeka Kolusu

I-elastin yomntu yenziwa kakhulu ukususela kwixesha lokugqibela lokukhula komntwana ukuya kwixesha lokuqala lokuzalwa, kwaye phantse akukho elastin intsha ifumanekayo ngexesha lokukhula. Iifayibha ze-elastic zenzeka utshintsho olwahlukileyo ngexesha lokwaluphala kwe-endogenous kunye ne-photoaging.

1. Isini kunye namalungu omzimba ahlukeneyo

Kwangowe-1990, ezinye iingcali zavavanya amavolontiya angama-33 ukuze zifunde ukuthamba kolusu kwiindawo ezili-11 zomzimba womntu.

Ibonisa ukuba ulusu luthambe kakhulu phakathi kwamalungu ahlukeneyo; nangona kungekho mahluko mkhulu phakathi kwamadoda nabafazi abahlukeneyo.

Ukuqina kolusu kuyehla kancinci kancinci xa ukhula.

2. Ubudala

Njengoko ulusu lukhula, ulusu oludala oluvela emvelweni aluguquguquki kwaye aluguquguquki kunesikhumba esiselula, kwaye inethiwekhi yefayibha elastiki iyaphuka kwaye iyancipha, ibonakalisa ukuba ulusu luyacaba kwaye lubhitye; ekwaluphaleni okuvela emvelweni, kungekuphela nje ukubola kwe-fibrous yeenxalenye ze-ECM, kodwa nokulahleka kwezinye iziqwenga ze-oligosaccharide. I-LTBP-2, i-LTBP-3, kunye ne-LOXL-1 zonke zaphuculwa, kwaye i-LTBP-2 kunye ne-LOXL-1 zidlala indima ebalulekileyo ekulawuleni nasekugcineni ukufakwa kwe-fibrin, ukuhlanganiswa, kunye nolwakhiwo ngokubopha i-fibulin-5. Ukuphazamiseka okunxulunyaniswa nokubonakaliswa kwezinto kuvela njengeendlela zokwandisa ukuguga okuvela emvelweni.

3. Izinto ezisingqongileyo

Umonakalo wezinto ezisingqongileyo eluswini, ikakhulu ukufota, ungcoliseko lomoya kunye nezinye izinto, uye waqwalaselwa kancinci kancinci, kodwa iziphumo zophando azicwangciswanga ngokwenkqubo.

Ulusu oluthatha imifanekiso luphawulwa kukuguqulwa kwe-catabolic kunye ne-anabolic kunye nokuguqulwa. Ulusu lubonakala lurhabaxa kwaye lushwabene kakhulu ngenxa yokulahlekelwa yi-microfibrils etyebileyo kwi-epidermis-dermal junction, ukuwohloka kwe-elastin, kodwa okubaluleke ngakumbi, kukubekwa kwezinto ezingasebenzi kakuhle kwi-dermis enzulu, umsebenzi we-elastin ochaphazelekileyo.

Umonakalo wesakhiwo kwiifayibha ze-elastic zesikhumba awunakuguqulwa ngaphambi kokuba ube neminyaka eli-18 ubudala, kwaye ukhuseleko lwe-UV lubalulekile ngexesha lokukhula. Kunokubakho iindlela ezimbini zokukhanya kwelanga kwefayibha ye-elastic: iifayibha ze-elastic zonakaliswa yi-elastase ekhutshwa ziiseli ezijikelezileyo okanye zikhanyiselwe yi-UV, kwaye iifayibha ze-elastic zigobile ngexesha lenkqubo yokwenza; ii-fibroblast zinefuthe lokukhuthaza iifayibha ze-elastic ukugcina ulungelelwano. Isiphumo siba buthathaka, nto leyo ebangela ukugoba.—— Yinmou Dong Iphephandaba leMishini yeeKhemikhali, 158-160

Inkqubo yokutshintsha kolusu oluthambileyo isenokungabonakali ngokwaneleyo emehlweni, kwaye singasebenzisa iingcaliisihlalutyi sokuxilonga ulusujonga kwaye uqikelele utshintsho oluza kwenzeka kwixesha elizayo kulusu.

Umzekelo,I-ISEMECO or Isihlalutyi solusu seResur, ngoncedo lokukhanya kobuchwephesha kunye nekhamera ecacileyo yokufunda ulwazi lolusu, kunye ne-algorithm yohlalutyo lwe-AI, banokubona iinkcukacha kunye nokubikezela utshintsho lolusu.