Indlela ye-squalene oxidation ixhomekeke ekubeni ixesha layo eliphantsi le-ionization linganikela okanye lifumane i-electron ngaphandle kokonakalisa isakhiwo se-molecular yeeseli, kwaye i-squalene inokuphelisa ukuphendulwa kwekhonkco le-hydroperoxides kwindlela ye-lipid peroxidation. Uphononongo lubonise ukuba i-peroxidation ye-sebum ibangelwa ikakhulu yi-oksijini ye-singlet, kwaye i-singlett oxygen quenching rate ye-squalene kwi-sebum yomntu inkulu kakhulu kunezinye iilipids eluswini lomntu. ukuphelelwa rhoqo. Nangona kunjalo, kufuneka kuqatshelwe ukuba nangona i-squalene inokuthintela i-lipid peroxidation, iimveliso ze-squalene, ezifana ne-unsaturated fatty acids, nazo zinefuthe elicaphukisayo kwesikhumba.
I-squalene peroxide inokudlala indima enkulu kwi-pathogenesis ye-acne. Kwiimodeli zovavanyo lwezilwanyana, kuye kwasekwa ukuba i-squalene monoperoxide i-comedogenic kakhulu, kwaye umxholo we-squalene peroxide ukhula ngokuthe ngcembe phantsi kwe-UV irradiation. Ngoko ke, kucetyiswa ukuba izigulane ze-acne zihlawule ingqalelo ekukhuselweni kwelanga, kwaye i-sunscreens inokuphepha i-squalene peroxidation kwi-physiological concentrations ebangelwa yimisebe ye-ultraviolet.
Umhlalutyi wesikhumbaingasetyenziselwa ukufumanisa umphumo we-sun cream. Umfanekiso we-UV uboniswa luhlaza bumnyama ukuba isikhuseli selanga sekhemikhali sifakiwe; ukuba i-sunscreen ebonakalayo isetyenziswe, umfanekiso ubonakalisa, ufana nentsalela ye-fluorescent.
Ixesha lokuposa: Apr-29-2022
