Indlela esebenza ngayo i-squalene oxidation kukuba ixesha layo eliphantsi le-ionization linokunikela okanye lifumane ii-electron ngaphandle kokonakalisa ulwakhiwo lweemolekyuli zeeseli, kwaye i-squalene inokuphelisa ukusabela kwe-chain ye-hydroperoxides kwindlela ye-lipid peroxidation. Izifundo zibonise ukuba i-peroxidation ye-sebum ibangelwa kakhulu yi-singlet oxygen, kwaye i-singlet oxygen quenching rate constant ye-squalene kwi-human sebum inkulu kakhulu kunezinye ii-lipids kulusu lomntu. Nangona kunjalo, kufuneka kuqatshelwe ukuba nangona i-squalene inokuthintela i-lipid peroxidation, iimveliso ze-squalene, ezifana ne-unsaturated fatty acids, nazo zinefuthe elicaphukisayo kulusu.
I-squalene peroxide inokudlala indima enkulu kwi-pathogenesis ye-acne. Kwiimodeli zovavanyo lwezilwanyana, kuye kwafunyaniswa ukuba i-squalene monoperoxide ibangela ukudumba okukhulu, kwaye umxholo we-squalene peroxide uyanda kancinci xa kutshiswa yi-UV. Ke ngoko, kucetyiswa ukuba izigulane ze-acne zifanele ziqwalasele ukukhuselwa lilanga, kwaye izithambisi zelanga zinokuphepha i-squalene peroxidation kumanqanaba e-physiological abangelwa yimitha ye-ultraviolet.
Isihlalutyi solusuingasetyenziselwa ukubona impembelelo yekrimu yelanga. Umfanekiso we-UV uboniswa uluhlaza okwesibhakabhaka ukuba kufakwe i-sunscreen yeekhemikhali; ukuba kufakwe i-sunscreen ebonakalayo, umfanekiso uyakhanya, ufana ne-fluorescent residue.
Ixesha lokuthumela: Epreli-29-2022
