Izinto ezintathu zokuguga kwesikhumba

Eyona nto iphambili ekugugeni kolusu:

imitha ye-UV, ukufota

I-70% yokuguga kwesikhumba ivela kwi-photoaging

Imitha ye-UV ichaphazela i-collagen emzimbeni wethu, egcina ulusu lubukeka luncinci. Ukuba i-collagen iyancipha, ulusu luya kuba luncitshisiwe u-elasticity, ukugoba, ubumnyama, ithoni yesikhumba engalinganiyo, i-hyperpigmentation, i-pigmentation kunye nezinye iingxaki zesikhumba.

Ilanga elibanzi lahlulahlulwe laba yi-UVA ne-UVB. Imitha ye-UVB inobude obufutshane kwaye inokutshisa kuphela umaleko ophezulu wolusu lwethu, ayikwazi ukungena nzulu eluswini; nangona kunjalo, imitha ye-UVA inobude obude kwaye inokungena ngeglasi kwaye ingene nzulu eluswini, ekugqibeleni yenza buthathaka i-collagen kwaye ikhokelele kuphuhliso lwemibimbi.

Ngamagama alula, i-UVA ikhokelela ekwaluphaleni, i-UVB ikhokelela ekutshisweni, kwaye ukukhanya kwe-ultraviolet kunokonakalisa i-DNA yeselula, kunciphise umsebenzi we-fibroblast, kunye ne-collagen synthesis ivaliwe, ekhokelela kuguquko lweeseli, ukuguga, kunye ne-apoptosis. Ke, i-UV ikuyo yonke indawo, nokuba linelanga okanye linamafu, kufuneka wenze umsebenzi olungileyo wokukhusela ilanga.

Into yesibini ebalulekileyo ekugugeni kwesikhumba

I-oxidative free radicals

Igama eliphambili leeradicals zasimahla ngu'oksijini'. Siphefumla malunga neepesenti ezingama-98 ukuya kuma-99 eoksijini ngalo lonke ixesha siphefumla; isetyenziselwa ukutshisa ukutya esikutyayo kwaye ikhuphe iimolekyuli ezincinci kwiiseli zethu ukuba zisebenze, kwaye ikhupha amandla amaninzi ukwenza imisipha yethu isebenze.

Kodwa mhlawumbi i-1% okanye i-2% ye-oksijeni ikhetha indlela eyahlukileyo kunye neyingozi, le mali encinci ye-oksijeni, edla ngokubizwa ngokuba yi-radicals yamahhala, ehlasela iiseli zethu. Ngokuhamba kwexesha, lo monakalo uqokelelana ngokuhamba kwexesha.

Eyona nto ibonakalayo yimiqondiso yokuguga ebonakala eluswini. Umzimba wethu unesixhobo sokuzikhusela esilungisa umonakalo owenziwe kwiiseli zethu ngeeradicals zasimahla, kodwa xa iiradicals zasimahla ziqokelelana ngokukhawuleza kunokuba iiseli zomzimba zinokuzilungisa, ulusu luguga ngokuthe ngcembe.

Lo mfanekiso ungentla yinyama yokwenyani yesikhumba somzimba wethu, ungabona ngokucacileyo ukuba i-epidermis ephezulu imnyama kwaye i-dermis esezantsi ikhanya kancinci, i-dermis kulapho sivelisa khona i-collagen, kwaye iiseli ezivelisa i-collagen zibizwa ngokuba yi-fibroblasts, oomatshini bokwenza i-collagen.

Iifibroblasts ezisembindini womfanekiso ziifibroblasts, kwaye i-spider web ejikelezileyo yicollagen. I-Collagen iveliswa zii-fibroblasts, kwaye ulusu oluncinci lunamacala amathathu kwaye ludityaniswe ngokuqinileyo lwe-collagen network, kunye ne-fibroblasts ezitsala ngamandla kwimicu ye-collagen ukunika ulusu oluncinci ukuthungwa okupheleleyo nokugudileyo.

Kwaye ulusu oludala, i-fibroblasts kunye nekhonkco ye-collagen phakathi kokuqhekeka kwe-fibroblasts egugayo iya kuhlala isala ukungena kwe-collagen, ngokuhamba kwexesha, ulusu lwaqala ukuguga, yile nto sihlala siyithetha ngokuguga kwesikhumba, siyisombulula njani i-oxidation ye-oxidation. ulusu lufunyenwe?

Ukongezelela ekuhlawuleni ingqalelo ngakumbi kwi-sunscreen, sinokusebenzisa ezinye nge-vitamin A, i-vitamin E, i-ferulic acid, i-resveratrol kunye nezinye izithako zemveliso yokunakekelwa kwesikhumba; ngokuqhelekileyo nako ukutya iziqhamo ezinemibala eqaqambileyo ngakumbi kunye nemifuno, ezifana iitumato, iitumato zizityebi lycopene.

Iyakwazi ukufunxa ioksijini kakuhle kwaye ithintele uxinzelelo lwe-oxidative, ungadla kwakhona i-broccoli, i-broccoli iqulethe icandelo elibizwa ngokuba yi-mustard oil glycosides, emva kokungeniswa kwesi sithako, ziya kugcinwa eluswini, ukuze iiseli zesikhumba zikwazi ukuzikhusela. , ezi ziqhamo kunye nemifuno inokukhuthaza ukuxhathisa kweeseli ekugugeni.

Into yesithathu ebalulekileyo ekugugeni kwesikhumba

Ukwandiswa kwesikhumba

I-Glycation, ngokwemiqathango yobuchwephesha, ibizwa ngokuba yi-non-enzymatic glycosylation reaction okanye i-Melad reaction. Umgaqo-siseko kukuba ukunciphisa ishukela kubophezela kwiiprotheni ngokungabikho kwe-enzymes; ukunciphisa iishukela ziguqulwa kakhulu kunye neeprotheni, kunye nokunciphisa iishukela kunye neeprotheni zihamba ixesha elide le-oxidation, i-dehydrogenation, kunye ne-rearrangement reaction, okubangelwa ukuveliswa kweemveliso zokugqibela ze-glycosylation, okanye i-AGEs emfutshane.

I-AGEs liqela lezinto ezingenakuguqulwa, ezi-yellow-brownish, ezinxulumene nenkunkuma yezinto eziphilayo ezingoyiki ukutshatyalaliswa kwe-enzyme, kwaye enye yezona zinto zibangela ukuguga kwabantu. Njengoko sineminyaka yobudala, i-AGEs iqokelela emzimbeni, ekhokelela ekwandeni kokuqina kweendonga zangaphakathi zemithambo yegazi, ukungalingani kwi-metabolism yamathambo ekhokelela kwi-osteoporosis, kunye nokutshatyalaliswa kwe-collagen kunye ne-elastin fibers kwi-dermis ekhokelela ekugugeni kwesikhumba. Ukuguga kwesikhumba okubangelwa yi-glycation kushwankathelwa kwisivakalisi esinye: iswekile itshabalalisa iiprotheyini eziphilileyo kwaye iguqule izakhiwo zeprotheyini ezincinci kwizakhiwo zeprotheni ezindala, ezikhokelela ekugugeni kunye nokulahlekelwa kwe-elasticity ye-collagen kunye ne-elastic fibers kwi-dermis.