Whitening Cosmetics kunyeIbala lebalaImetabolism
I-Melanin anabolism ihlukaniswe ngamaxesha ahlukeneyo. Izazinzulu zikholelwa ukuba kuyenzeka ukufunda iiarhente ezimhlophe kunye nokusebenza ngamaxesha ahlukeneyo e-metabolic.
(1) Inqanaba lokuqala le-melanin synthesis
① Ukuphazamisa ushicilelo kunye/okanye i-glycosylation ye-tyrosinase; ② Ukuthintela abalawuli ekuqulunqweni kwe-tyrosinase; ③ Ukulawulwa kwe-post-transcription ye-tyrosinase.
(2) Ixesha le-Melanin synthesis
Njenge-enzyme ephambili kunye nesantya sokunciphisa i-enzyme ye-melanin synthesis, i-tyrosinase inhibitors yeyona nto iphambili yophando kunye nesikhokelo sophuhliso okwangoku. Ekubeni uninzi lwee-agent ezimhlophe ezifana ne-phenol kunye ne-catechol derivatives zifana ne-tyrosine kunye ne-dopa, ii-agent ezimhlophe ezihlolwe zihlala zihlelwa njenge-non-competitive or competitive inhibitors ye-tyrosinase.
(3) Inqanaba lokugqibela le-melanin synthesis
①Ithintela ukudluliselwa kwemelanosome; izinto ezine-serine protease inhibitory effect, ezifana ne-rwj-50353, ziphephe ngokupheleleyo i-UBV-induced epidermal pigmentation; Isoya ye-trypsin inhibitor inesiphumo esicacileyo sokwenza mhlophe kodwa ayinasiphumo kwityhefu yeeseli ze-pigment; I-Niacinamide, inokuthintela ukuhanjiswa kwee-melanocytes phakathi kwe-melanocytes kunye ne-keratinocytes; ② Ukuchithwa kwe-melanin kunye ne-metabolism, i-α-hydroxy acid, i-fatty acid yamahhala kunye ne-retinoic acid, ivuselela ukuvuselelwa kweeseli kunye nokukhuthaza i-melaninized keratinocytes yokususwa.
Kuyafaneleka ukuba uqaphele ukuba uphando kunye nokusetyenziswa kwezinto ezimhlophe ezisekelwe kwi-metabolism engentla ye-melanin ayifanelekanga ukukhusela kunye nokunyangwa kwee-senile plaques. Ekubeni indlela yokubunjwa kwe-senile plaque ihambelana nokubunjwa kwe-lipofuscin, izinto ezisebenzayo ze-antioxidative zisetyenziselwa ukulibaziseka kunye nokubuyisela umva amacwecwe e-senile.
Ixesha lokuposa: Jul-29-2022
