Izinto zokuhombisa ezimhlophe kunyeIbalaI-Metabolism
I-Melanin anabolism yahlulwe ngamaxesha ahlukeneyo. Izazinzulu zikholelwa ukuba kunokwenzeka ukufunda izinto ezibangela ukuba umntu abe mhlophe kwaye zisebenze ngamaxesha ahlukeneyo e-metabolic.
(1) Inqanaba lokuqala lokwenziwa kwe-melanin
① Iphazamisana nokubhalwa kunye/okanye i-glycosylation ye-tyrosinase; ② Ithintela abalawuli ekwakhiweni kwe-tyrosinase; ③ Ulawulo lwe-tyrosinase emva kokubhalwa.
(2) Ixesha lokwenziwa kweMelanin
Njenge-enzyme ephambili kunye ne-enzyme ethintela izinga lokwenziwa kwe-melanin, ii-tyrosinase inhibitors zezona ndlela ziphambili zophando nophuhliso okwangoku. Ekubeni uninzi lwee-agents zokwenza mhlophe ezifana ne-phenol kunye ne-catechol derivatives zifana ngokwesakhiwo ne-tyrosine kunye ne-dopa, ii-agents zokwenza mhlophe ezihlolweyo zihlala zihlelwa njengezithinteli ezingakhuphisaniyo okanye ezikhuphisanayo ze-tyrosinase.
(3) Inqanaba lokugqibela lokwenziwa kwe-melanin
①Ithintela ukudluliselwa kwe-melanosome; izinto ezinefuthe lokuthintela i-serine protease, ezifana ne-rwj-50353, zithintela ngokupheleleyo i-pigmentation ye-epidermal ebangelwa yi-UBV; i-soybean trypsin inhibitor inefuthe elicacileyo lokuba mhlophe kodwa ayinampembelelo kwityhefu yeeseli ze-pigment; i-Niacinamide, inokuthintela ukudluliselwa kwe-melanocytes phakathi kwe-melanocytes kunye ne-keratinocytes; ② Ukusasazwa kwe-Melanin kunye ne-metabolism, i-α-hydroxy acid, i-free fatty acid kunye ne-retinoic acid, ivuselela ukuvuselelwa kweeseli kwaye ikhuthaza ukususwa kwe-melaninized keratinocytes.
Kubalulekile ukuqaphela ukuba uphando kunye nokusetyenziswa kwezinto zokwenza mhlophe ezisekelwe kwi-metabolism ye-melanin engentla azifanelekanga ukuthintela nokunyanga ii-penis ezidala ukonakala. Ekubeni indlela yokwakheka kwe-penis ezidala ukonakala inxulumene nokwakheka kwe-lipofuscin, izinto ezisebenzayo ze-antioxidative zihlala zisetyenziselwa ukulibazisa nokubuyisela umva ii-penis ezidala ukonakala.
Ixesha lokuthumela: Julayi-29-2022
